Hypokalemia

Causes
Potassium is needed for cells, especially nerve and muscle cells, to function properly. You get potassium through food. The kidneys remove excess potassium in the urine to keep a proper balance of the mineral in the body.

Hypokalemia is a metabolic disorder that occurs when the level of potassium in the blood drops too low.

Possible causes of hypokalemia include:

• Antibiotics (penicillin, nafcillin, carbenicillin, gentamicin, amphotericin B, foscarnet)
• Diarrhea (including the use of too many laxatives, which can cause diarrhea)
• Diseases that affect the kidneys' ability to retain potassium (Liddle syndrome, Cushing syndrome, hyperaldosteronism, Bartter syndrome, Fanconi syndrome)
• Diuretic medications, which can cause excess urination
• Eating disorders (such as bulimia)
• Eating large amounts of licorice or using products such as herbal teas and chewing tobaccos that contain licorice made with glycyrrhetinic acid (this substance is no longer used in licorice made in the United States)
• Magnesium deficiency
• Sweating
• Vomiting

Symptoms
A small drop in potassium usually doesn't cause symptoms. However, a big drop in the level can be life threatening.

Symptoms of hypokalemia include:

• Abnormal heart rhythms (dysrhythmias), especially in people with heart disease
• Constipation
• Fatigue
• Muscle damage (rhabdomyolysis)
• Muscle weakness or spasms
• Paralysis (which can include the lungs)

Exams and Tests
Your health care provider will take a sample of your blood to check potassium levels.

Other tests might include:

• Arterial blood gas
• Basic or comprehensive metabolic panel
• Electrocardiogram (ECG)
• Blood tests to check glucose, magnesium, calcium, sodium, phosphorous, thyroxine, and aldosterone levels

Treatment
Mild hypokalemia can be treated by taking potassium supplements by mouth. Persons with more severe cases may need to get potassium through a vein (intravenously).

If you need to use diuretics, your doctor may switch you to a form that keeps potassium in the body (such as triamterene, amiloride, or spironolactone).

One type of hypokalemia that causes paralysis occurs when there is too much thyroid hormone in the blood (thyrotoxic periodic paralysis). Treatment lowers the thyroid hormone level, and raises the potassium level in the blood.

Outlook (Prognosis)
Taking potassium supplements can usually correct the problem. In severe cases, without proper treatment a severe drop in potassium levels can lead to serious heart rhythm problems that can be fatal.

Possible Complications
In severe cases, patients can develop paralysis that can be life threatening. Hypokalemia also can lead to dangerous irregular heartbeat. Over time, lack of potassium can lead to kidney damage (hypokalemic nephropathy).

When to Contact a Medical Professional
Call your health care provider if you have been vomiting or have had excessive diarrhea, or if you are taking diuretics and have symptoms of hypokalemia.

Prevention
Eating a diet rich in potassium can help prevent hypokalemia. Foods high in potassium include:

• Avocados
• Bananas
• Bran
• Carrots
• Dried figs
• Kiwi
• Lima beans
• Milk
• Molasses
• Oranges
• Peanut butter
• Peas and beans
• Seaweed
• Spinach
• Tomatoes
• Wheat germ

Alternative Names
Potassium - low; Low blood potassium

References
Mount DB, Zandi-Nejad K. Disorders of potassium balance. In: Brenner BM, ed. Brenner and Rector's The Kidney . 8th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 15.

Seifter JL. Potassium disorders. In: Goldman L, Ausiello D, eds. Cecil Medicine . 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 118.

Update Date: 5/29/2011
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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